caprotec bioanalytics Announces the Successful Completion of a Collaborative Research Project With Roche
To identify selectively interacting proteins of a drug molecule, it is coupled to caprotec’s Capture Compound™ scaffold and incubated with human cell lysates, subcellular fractions or whole cells. Interacting proteins are then isolated and identified via Liquid Chromatography-Mass Spectrometry/Mass. Among the protein targets that demonstrated specific binding of Roche’s drug molecule were some which show activity in pathways commensurate with the phenotypic profile of the candidate drug molecule.
“The results of this drug-protein profiling study confirm again the capability of our CCMS technology to directly isolate a functional subset of proteins from a complex biological sample for the identification of previously unknown interactions with small molecules,” said Dr. Hubert Köster, CEO of caprotec. “This fills a crucial technological gap in the arsenal of methods available for optimizing drug structures and to select the most promising candidate drugs before entering the clinical trial process as well as drug safety assessment.”
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