Better Insight into Brain Anatomical Structures
Manganese oxide nanoparticles as contrast agents for brain magnetic resonance imaging
Magnetic resonance images after injection of the manganese oxide nanoparticles gave a view into different areas of the mouse brains - in excellent resolution. "We have developed the first truly biocompatible MRI contrast agent for anatomical brain imaging," Lee and Hyeon point out. "With this agent, we are able to get high-contrast views of the anatomical details of live mouse brain." The researchers hope that their new contrast agent will allow better research and diagnosis of brain diseases involving the CNS (central nervous system), such as Alzheimer's disease, Parkinson's disease, strokes, and tumors.
Furthermore, the Korean team was able to attach antibodies to the manganese oxide nanoparticles. These antibodies recognize and specifically bind to receptors on the surface of breast cancer cells. In mouse brains with breast cancer metastases, the tumors were clearly highlighted by the antibody-coupled contrast agent. The same principle should allow other disease-related changes or physiological systems to be visualized by using the appropriate antibodies.
Original publication: Taeghwan Hyeon et al.; "Development of a T1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles"; Angewandte Chemie International Edition 2007.
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