New Online Analysis Optimizes Drying Processes in the Pharmaceutical Industry
drying processes are an important part of the production of intermediate and end products in the pharmaceutical industry. In addition to the determination of a suitable temperature and pressure, the automatic recognition of the production end point is a crucial factor when optimizing processes.
Through the use of online analysis with a mass spectrometer (MS), the end point of the drying process can be determined and documented with precision and without the need for costly and time-consuming manual sampling. In the USA, for example, the FDA's (Food and Drug Administration) PAT initiative calls for the closest possible supervision and coordination of the entire production process in the manufacture of pharmaceutical products. The implementation of this model can be of great significance for the international pharmaceutical industry.
The end of the drying process is reached at different times depending on the method of drying and the size and character of the batch. As a rule the end point is determined by way of manual samplings and off-line so-called loss of drying tests in the laboratory. In contrast, the online analysis using an MS provides an extremely fast and automated solution. The exhaust air, and consequently the drying progress, is constantly monitored and documented. This is possible with an MS both under normal pressure and in the case of vacuum drying at a pressure of 1 to 1200 mbar. The mass spectrometric online analysis can also be used to establish optimal drying temperature and pressure. Process optimisation offers advantages in terms of more efficient use of plants and facilities as well as provides increased consistency in the product quality. Moreover, the resulting savings in time and energy also mean greater cost-effectiveness.
InProcess Instruments have recently published a report , in which they document these applications for their quadrupole mass spectrometers. The report can be downloaded from their internet site.
Other news from the department research and development
These products might interest you
PlasmaQuant MS Elite by Analytik Jena
LC-ICP-MS Is the Key to the World of Elemental Species
Highest Sensitivity and Lowest Detection Limits with PlasmaQuant MS Series and PQ LC
IonTamer ToF MS by Spacetek Technology
IonTamer instruments are time-of-flight residual gas analysers (TOF-RGA) for the analysis of gases
Compact Time-of-flight residual gas analyzer (TOF-RGA) for process analysis
Xevo TQ Absolute by Waters
A new Tandem Quadrupole Mass Spectrometer for Quantification with Absolute power
Absolute performance, efficiency, productivity, and confidence for your most challenging compounds
iCAP RQ single Quadrupole ICP-MS by Thermo Fisher Scientific
Robust ICP-MS with ease of use and high productivity for routine analysis
A complete multi-element analysis solution for your high-throughput routine laboratory
iCAP TQ Triple Quadrupole ICP-MS by Thermo Fisher Scientific
Overcome unexpected interferences, reduce detection limits and improve data quality
Ultralow limits of detection with simplicity - even for the most challenging analytical applications
Thermo Scientific TSQ Triple Quadrupole Mass Spectrometry Systems by Thermo Fisher Scientific
Confident quantitation with triple quadrupole LC-MS systems
Mass Spectrometry Systems
TSQ 9610 GC-MS/MS by Thermo Fisher Scientific
TSQ 9610 GC-MS/MS for superb sensitivity and selectivity with outstanding reliable productivity
Eliminate unnecessary, unplanned instrument downtime, save helium and maximize productivity
Get the analytics and lab tech industry in your inbox
From now on, don't miss a thing: Our newsletter for analytics and lab technology brings you up to date every Tuesday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!
Topic World Spectroscopy
Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!
