Analytics - 20 News from the science department by Max-Planck-Gesellschaft for the bioanalytics industry

Analytics - 20 News from the science department by Max-Planck-Gesellschaft for the bioanalytics industry

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New tool maps microbial diversity with unprecedented details

The innovative tool allows the analysis of structural genomic variations in microbial populations

26-Jun-2024 - Researchers from the Max Planck Institute for Biology Tübingen developed the groundbreaking tool SynTracker. SynTracker expands traditional microbial analysis by considering genomic structural variation to complement existing SNP-based methods. This innovation reveals more precision and depths of ...

analytics evolution genome analysis
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The enzyme with the iron heart

Results could lead to new biocatalysts for sustainable biotechnology

11-Dec-2023 - Nitrogenases are the only enzymes capable of reducing atmospheric nitrogen to bioavailable nitrogen (ammonia), a process essential for all life on Earth. Using cryogenic electron microscopy, researchers at the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany, have now solved ...

analytics bacteria biocatalysts
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Analysis of single plant cells provides insights into natural product biosynthesis

Single-cell multi-omics reveals that cell types are differentially involved in the production and accumulation of medically relevant plant compounds

19-May-2023 - In a new study published in Nature Chemical Biology, an international team of researchers from the University of Georgia, USA, and the Max Planck Institute for Chemical Ecology in Jena, Germany, presents a promising strategy for elucidating metabolic pathways for plant compounds of medicinal ...

analytics active ingredients alkaloids
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Beethoven’s genome: New study reveals hereditary diseases and a family mystery

Scientists have sequenced the composer’s genome using five genetically matching hair locks

24-Mar-2023 - The study shows Beethoven was predisposed to liver disease, and infected with Hepatitis B, which – combined with his alcohol consumption – may have contributed to his death. Furthermore, DNA from modern relatives points to an extramarital ‘event’ in Beethoven’s paternal line. Johannes Krause, ...

analytics alcohol consumption deafness
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The architecture of shattered genomes

Hunting for disease clues in the dark matter of our DNA

20-Jan-2023 - Scientists have reconstructed the chromosomes of patients with an extremely high number of aberrations in their genome that could alter the expression of nearby genes and potentially cause disease. Their results were published in Nature Communications in October 2022. “We are only beginning to ...

analytics chromosomes chromothripsis
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How to find marker genes in cell clusters

New method facilitates identification of cell-type specific genes in single-cell data

06-Jul-2022 - The thousands of cells in a biological sample are all different and can be analyzed individually, cell by cell. Based on their gene activity, they can be sorted into clusters. But which genes are particularly characteristic of a given cluster, i.e. what are its “marker genes”? A new statistical ...

analytics bioinformatics cell analysis
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DNA in archaeological sediments

Ancient human and animal DNA can remain stably localized in sediments, preserved in microscopic fragments of bone and feces

06-Jan-2022 - The analysis of ancient DNA preserved in sediments is an emerging technology allowing for the detection of the past presence of humans and other animals at archaeological sites. Yet, little is known about how DNA is preserved in sediment for long periods of time. An international team of ...

analytics deoxyribonucleic acid DNA
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Molecular scales on biological membranes: Mass-Sensitive Particle Tracking

New method to determine location and size changes of unlabeled proteins on membranes via their mass

06-Oct-2021 - A large proportion of biologically relevant processes take place at membranes. Studying the dynamics of these processes in real time and without disturbing the biological system is still a major methodological challenge. A team led by Petra Schwille, director at the MPI of Biochemistry (MPIB), ...

analytics cell membranes mass determination
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MaxDIA – taking proteomics to the next level

Highly sensitive and accurate data analysis: New software improves data-independent acquisition proteomics

12-Jul-2021 - Proteomics produces enormous amounts of data, which can be very complex to analyze and interpret. The free software platform MaxQuant has proven to be invaluable for data analysis of shotgun proteomics over the past decade. Now, Jürgen Cox, group leader at the Max Planck Institute of ...

analytics data analysis machine learning
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Speeding up sequence alignment across the tree of life

A sequence search engine for a new era of conservation genomics

09-Apr-2021 - A team of researchers from the Max Planck Institutes of Developmental Biology in Tübingen and the Max Planck Computing and Data Facility in Garching develops new search capabilities that will allow to compare the biochemical makeup of different species from across the tree of life. Its ...

analytics databases genome analysis
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