A cellular model system for drug development in fatty liver disease

A 3D in vitro cell culture model as a basis for the development of new treatment strategies for one of the most common diseases in industrialized nations

12-Sep-2024 - Scientists from the Medical Faculty Mannheim, Heidelberg University have developed a model system that can be used to test the efficacy of drugs for fatty liver disease. It is a three-dimensional (3D) in vitro cell culture system based on primary human liver parenchymal cells (hepatocytes). The ...

Programmable DNA hydrogels for advanced cell culture and personalized medicine

21-Aug-2023 - The team of Dr. Elisha Krieg at the Leibniz Institute of Polymer Research Dresden has developed a dynamic DNA-crosslinked matrix (DyNAtrix) by combining classical synthetic polymers with programmable DNA crosslinkers. DNA’s highly specific and predictable binding gives researchers unparalleled ...

Successfully reducing animal testing: The 3Rs principle in fish research

Investigation of cell cultures provides insights into climate change

23-Jun-2023 - According to animal experimentation statistics, fish are the second most commonly used group of animals in research after mice. They play an important role in aquaculture and also serve as model animals in various research areas. "Applying the 3Rs principle means reducing, refining and replacing ...

Where do toxins from tobacco attack DNA?

In the future, this could make it easier than ever to determine the safety of many chemical substances

24-Feb-2023 - It is known that toxins in tobacco smoke can change our DNA – but where exactly in the genome they do this has been a mystery. A new approach developed by researchers at ETH Zurich now brings light into the darkness. In the future, this could make it easier than ever to determine the safety of ...

Thermo Fisher Scientific announces collaboration with Celltrio

Unlock fully automated cell line production

08-Feb-2023 - Thermo Fisher Scientific and Celltrio, a manufacturer of robotics-based solutions for the life sciences industry, have announced their collaboration to bring a fully automated cell culture system to biotherapeutics customers. The collaboration will integrate the Thermo Scientific Momentum ...

Model system provides insight into the growth of pancreatic tumors

Researchers develop innovative organoid model to study pancreatic cancer

07-Oct-2022 - Researchers at the Technical University of Munich (TUM) have developed a novel model system that can be used to precisely track the growth steps and three-dimensional arrangement of pancreatic cancer cells. It also provides the basis for testing and developing therapeutic approaches. Pancreatic ...

A novel painless and reliable allergy test

In vitro mast cells provide unprecedented reliability

23-Mar-2022 - Although allergies are widespread, their diagnosis is complex and, depending on the type of allergy, the prospects of success with therapy are not always clear. Skin tests so far have been unpleasant, time-consuming and associated with a certain risk of triggering an allergic overreaction. ...

New light source: A million times brighter than the sun

PhD thesis investigated application of a special white-light laser for semiconductor industry and microbiology

14-Feb-2022 - A new high-performance white-light laser is expected to speed up quality control in the semiconductor industry and provide closer monitoring of toxicity tests in microbiology. In one step, this laser enables the two-sided characterization of surfaces and can be integrated into production chains. ...

Cytiva and Pall Corporation investing 1.5 billion USD over two years to meet growing demand for biotechnology solutions

Major investments are expanding manufacturing capacity for life sciences products at 13 Cytiva and Pall Corporation sites helping to meet customer demand.

03-Aug-2021 - An ongoing strategic growth plan from Cytiva and Pall Corporation, part of the Danaher Corporation, will expand manufacturing capacity and services across geographies for global life sciences customers. The investment, already underway, includes new sites, expansion at existing factories, and is ...

Toxicity testing on the placenta and embryo

Detection substances that are harmful to the embryo at an early stage of drug development

23-Jul-2021 - Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments. Drugs ...