What triggers the programmed cell death mechanism?

Development and combination of various microscopic and spectroscopic techniques

13-Sep-2024 - How can molecular structures be analysed when the resolution of the techniques available is not sufficient? Researchers from the fields of physics, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU) have combined and further developed various microscopic and spectroscopic ...

Bacterial membrane transporter helps pathogens to hide from immune system

"Our results represent a real breakthrough, since attempts to decipher the structure of a TRAP transporter had already been going on for about 20 years"

11-Aug-2022 - The transport of substances across the membrane into the cell is linked to specific membrane transport proteins. Researchers at the University Hospital Bonn (UKB) and the University of Bonn, in collaboration with an international team, have now succeeded in elucidating the molecular structure of ...

Lew lab sheds new light on cell membranes

Researchers can now image cells, motions of molecules in 6D

31-May-2022 - Research from the lab of Matthew Lew at Washington University in St. Louis offers entirely new ways to see the very small. The research — two papers by PhD students at the McKelvey School of Engineering — was published in the journals Optica and Nano Letters. They have developed novel hardware ...

Cell Membranes in Super Resolution

For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes

04-Dec-2020 - Expansion microscopy (ExM) enables the imaging of cells and their components with a spatial resolution far below 200 nanometres. For this purpose, the proteins of the sample under investigation are cross-linked into a swellable polymer. Once the interactions between the molecules have been ...

Molecular energy machine as a movie star

09-Jul-2019 - Researchers at the Paul Scherrer Institute PSI have used the Swiss Light Source SLS to record a molecular energy machine in action and thus to reveal how energy production at cell membranes works. For this purpose they developed a new investigative method that could make the analysis of cellular ...

Bringing information into the cell

30-Apr-2019 - Researchers at the Paul Scherrer Institute PSI have elucidated an important part of a siganalling pathway that transmits information through the cell membrane into the interior of a cell. This siganalling pathway is of great significance for all mammals, since it is involved in various important ...

Theory unlocks the secret behind protein-membrane interactions

Understanding cell behavior better by elucidating how proteins work with cell membranes

28-Jan-2019 - Trillions of cells -- all different shapes and sizes -- form a human body's structure. Surrounding each cell is a membrane, jointly acting as hostess and security -- welcoming certain information into the cell while making sure its components don't spill out into the body's void. Much is known ...

How Salmonella 'die' at low temperatures

08-Feb-2018 - The most economical way to kill bacteria that cause common food-borne illnesses -- mostly caused by Salmonella enterica -- is heat, but, the mechanisms that kill Salmonella at lower temperatures were not fully understood until now, according to a team of researchers. Bacteria can develop ways to ...

Opening the cavity floodgates

Biochemists investigate the transport of large proteins through bacterial cell membranes

25-Jan-2018 - Every cell is surrounded by a membrane, which ensures the internal biochemical milieu and regulates the exchange of substances with its surroundings. In every cell membrane, there are a large number of transporters that allow only one sort of molecule to pass through. In the case of very small ...

Membrane vesicles released by bacteria may play different roles during infection

18-Sep-2017 - Bacteria release membrane-derived vesicles (MVs), which are small particles that can transport virulence factors to neighbouring bacteria or to the cells of a mammalian host. This special MV-based system for delivering toxic proteins and nucleic acids in a protected manner to the target cells may ...