WildDISCO: Visualizing Whole Bodies in Unprecedented Detail

AI Integration: Predicting Disease Progression Without the Use of Animal Models in Research

12-Jul-2023 - Researchers developed a new method called wildDISCO that uses standard antibodies to map the entire body of an animal using fluorescent markers. This revolutionary technique provides detailed 3D maps of structures, shedding new light on complex biological systems and diseases. WildDISCO has the ...

New technique shows in detail where drug molecules hit their targets in the body

The new method could speed the development of many new drugs

03-May-2022 - Scientists at Scripps Research have invented a way to image, across different tissues and with higher precision than ever before, where drugs bind to their targets in the body. The new method could become a routine tool in drug development. Described in a paper in Cell on April 27, 2022, the new ...

Super-Resolution RNA Imaging in Live Cells

Innovative method provides new insight into molecular processes involving RNA

02-Mar-2021 - Ribonucleic acid (RNA) is key to various fundamental biological processes. It transfers genetic information, translates it into proteins or supports gene regulation. To achieve a more detailed understanding of the precise functions it performs, researchers based at Heidelberg University and at ...

Formation of quadruple helix DNA tracked in live human cells for the first time

The biology of DNA must be rethink

23-Jul-2020 - The formation of four-stranded DNA has been tracked in living human cells, allowing scientists to see how it works, and its possible role in cancer. DNA usually forms the classic double helix shape discovered in 1953 - two strands wound around each other. Several other structures have been formed ...

Imaging nerve-cell interactions

04-Jan-2019 - A new imaging technique developed by LMU researchers is garnering lots of attention. Based on a method for making tissues, organs and even whole organisms transparent, it promises to transform studies of the nervous system in particular. A new bioimaging technology provides unprecedented insights ...

Researchers combine light and X-ray microscopy for comprehensive insights

11-Sep-2018 - Researchers at the University of Goettingen have used a novel microscopy method. In doing so they were able to show both the illuminated and the "dark side" of the cell. The team led by Prof. Dr. Tim Salditt and Prof. Dr. Sarah Köster from the Institute of X-Ray Physics "attached" small ...

Maelstroms in the heart

New, promising imaging technique for cardiac arrhythmias

23-Feb-2018 - Every five minutes in Germany alone, a person dies of sudden cardiac arrest or fibrillation, the most common cause of death worldwide. This is partly due to the fact that doctors still do not fully understand exactly what goes on in the heart during the occurrence. Until now, it was impossible to ...

Long-Sought ‘Warm-Sensitive’ Brain Cells Identified in New Study

09-Sep-2016 - A new UC San Francisco study challenges the most influential textbook explanation of how the mammalian brain detects when the body is becoming too warm, and how it then orchestrates the myriad responses that animals, including humans, use to lower their temperature—from “automatic” ...

The 2011 Körber Prize goes to Stefan Hell

With a groundbreaking idea the physicist has overcome the diffraction resolution barrier in optical microscopy

08-Jul-2011 - Prof. Dr. Dr. h. c. Stefan Hell of the Max Planck Institute for Biophysical Chemistry in Göttingen is to receive the 2011 Körber European Science Prize endowed with 750,000 euros for his pioneering discoveries in the field of optics. Every year, the Körber Prize is awarded to an outstanding ...

Visualising DNA sequences

20-Aug-2010 - A new, fast way to analyse DNA could be used to sequence the genomes of viruses and in the future help tackle genetic disorders such as schizophrenia and congenital heart defects. Robert Neely and colleagues have used a DNA methyltransferase enzyme to label the 5’-GCGC-3’ DNA sequences with a ...