Cross-species cancer comparison uncovers new drug targets

Drug targets for a form of melanoma from genetic mutations found in humans, dogs and horses

13-Feb-2019 - New drug targets for a rare form of melanoma may result from the discovery of similar genetic mutations found in humans, dogs and horses under a first-ever tri-species DNA sequencing study involving a University of Guelph researcher. Melanoma is a cancer that most commonly occurs in the skin in ...

Genome Duplication Drives Evolution of Species

26-Sep-2018 - Polyploid plants have a duplicate set of chromosomes. As a result, large-scale genetic changes are therefore possible in the new species, making it more adaptable in comparison with the parental species, as has now been proven by UZH researchers with rockcress. Many wild and cultivated plants ...

How the most common DNA mutation happens

05-Feb-2018 - Researchers describe how two normally mismatched bases in human DNA, guanine and thymine, are able to change shape in order to form an inconspicuous rung on the helical DNA "ladder." This allows them to survive by avoiding the body's natural defenses against genetic mutations. "When these two ...

Genetic model identifies primary myelofibrosis outcomes

11-Dec-2017 - A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease. The group's findings ...

Revolutionary imaging technique uses CRISPR to map DNA mutations

22-Nov-2017 - A team of scientists led by Virginia Commonwealth University physicist Jason Reed, Ph.D., have developed new nanomapping technology that could transform the way disease-causing genetic mutations are diagnosed and discovered. Described in a study this novel approach uses high-speed atomic force ...

Ancient DNA can both diminish and defend modern minds

03-Jan-2017 - You've likely heard about being in the right place at the wrong time, but what about having the right genes in the wrong environment? In other words, could a genetic mutation (or allele) that puts populations at risk for illnesses in one environmental setting manifest itself in positive ways in a ...

Illumina and Wellcome Trust Sanger Institute Announce Completed Genome for Endangered Tasmanian Devil

Uncovering Mutations Found in Deadly Transmissible Cancer Could Help Conservation Efforts

20-Sep-2010 - Researchers from Illumina, Inc. and the Wellcome Trust Sanger Institute have used Illumina's next generation sequencing technology to create a draft genome sequence for the endangered Tasmanian devil, and will use this to find genetic mutations in the transmissible cancer that is ravaging its ...

Exonhit to Acquire Redpath Integrated Pathology, Inc.

Complementary fit between RedPath’s DNA platform and ExonHit’s RNA platform

27-Apr-2010 - ExonHit Therapeutics S.A. announced that it entered into a binding agreement for the acquisition of RedPath Integrated Pathology, Inc., a privately held molecular diagnostics company, focused on cancer. RedPath will become part of ExonHit’s US operations. Headquartered in Pittsburgh, ...

Einstein researchers find molecular structure of key fluorescent proteins

26-Apr-2010 - Scientists at Albert Einstein College of Medicine of Yeshiva University have determined the crystal structures of two key fluorescent proteins – one blue, one red – used to "light up" molecules in cells. That finding has allowed them to propose a chemical mechanism by which the red color in ...

Using yeast to identify cancer genes

Researchers use yeast to identify cancer-causing genes that may also occur in humans

31-Jul-2009 - Identifying cancer-causing genes is a major challenge, but now Cornell scientists have devised a technique using yeast cells to identify new cancer genes that may also be found in humans. The study, published in Public Library of Science Biology, is the first to report on mutations in yeast that ...