Scientists use quantum biology, AI to sharpen genome editing tool

"This study represents an exciting advancement toward, understanding how we can avoid making costly ‘typos’ in an organism’s genetic code"

21-Nov-2023 - Scientists at Oak Ridge National Laboratory used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals. CRISPR is a powerful tool ...

Information about a gene that helps define us as humans

07-Dec-2018 - University of Otago researchers have discovered information about a gene that sets primates - great apes and humans - apart from other mammals, through the study of a rare developmental brain disorder. Dr Adam O'Neill carried out the research as part of his PhD at the University of Otago, under ...

New informatics tool makes the most of genomic data

13-Jul-2018 - The rise of genomics, the shift from considering genes singly to collectively, is adding a new dimension to medical care; biomedical researchers hope to use the information contained in human genomes to make better predictions about individual health, including responses to therapeutic drugs. A ...

Study of COPD patients has created a 'looking glass' into genome of pathogen

21-Mar-2018 - Decades of work on chronic obstructive pulmonary disease (COPD) at the University at Buffalo and the Veterans Affairs Western New York Healthcare System have yielded extraordinary information about the pathogen that does the most harm to patients. The results provide the first insights into how ...

Genome architecture caught in motion

12-Oct-2017 - Researchers at The Wistar Institute have uncovered new aspects of the three-dimensional organization of the genome, specifically how the genetic material is compacted and de-compacted in a timely fashion during the different phases of the cell cycle. "We are just starting to appreciate that the ...

Unknown virus in ‘throwaway’ DNA discovered

A chance discovery has opened up a new method of finding unknown viruses

07-Aug-2017 - In research scientists from Oxford University’s Department of Zoology have revealed that Next-Generation Sequencing and its associated online DNA databases could be used in the field of viral discovery. They have developed algorithms that detect DNA from viruses that happen to be in the blood or ...

'Overturning established fact' leads to new new target in MLL-rearranged leukemia

15-Jun-2017 - The human gene MLL is named for the mixed lineage leukemia it creates. Specifically, the gene may break apart and fuse with parts from one of a number of other genes on other chromosomes to create cancer-causing translocations. These translocations make new proteins that have never been seen by ...

First complete interactome map of human receptor tyrosine kinases and phosphatases

09-Jan-2017 - In 2011, Igor Stagljar, a professor in the University of Toronto's Donnelly Centre, came across a study that genetically linked two genes in the cell to a hard-to-treat (triple negative) breast cancer. It was not clear how the proteins encoded by these genes worked, but Stagljar had a unique way ...

NovogeneAIT Singapore and the Genome Institute of Singapore forge Public-Private Partnership

Establishing whole genome sequencing centre in Singapore

08-Dec-2016 - Novogene, a commercial provider of genomic services and solutions with cutting edge next-generation sequencing and bioinformatics expertise; AITbiotech Pte Ltd, a Singapore biotechnology company; and the Genome Institute of Singapore (GIS) announced today that NovogeneAIT Genomics Singapore ...

Watermelon genome decoded

Decoded genome paves way for better watermelons

29-Nov-2012 - Sweeter and more disease-resistant watermelons just may be on their way, thanks to an international consortium of more than 60 scientists that has just published the genome sequence of watermelon (Citrullus lanatus). Such information could dramatically accelerate breeding to produce more ...