“Multi Organ Model” - Animal-free alternative for pharmacokinetics research

Dynamic42 and research partners present three-organ system to reduce animal testing

20-Feb-2025 - Organ-on-chip specialist Dynamic42 and ESQlabs, experts in digital life sciences solutions, have successfully developed a three-organ system, in close collaboration with Consumer Health Division of Bayer, and the Placenta Lab at Jena University Hospital. The platform has the potential to ...

Tumor tissue on a chip: new possibilities for cell therapies and personalized medicine

Therapy effect becomes predictable: Monitoring success individually and in real time

17-May-2024 - How do tumors react to a certain therapeutic approach? Knowing this before the start of a therapy would be of enormous value for people suffering from cancer as well as for the doctors treating them. Researchers at the NMI Natural and Medical Sciences Institute in Reutlingen and the University ...

An intestinal chip model takes research of fungal infections to a new level

Successful cooperation between science, clinic and start-up

25-Mar-2024 - The Jena-based biotech company Dynamic42 has developed an intestine-on-chip candidiasis model that allows for the quantification of the infection process. By combining microbiological and image-based analyses, the pathogen-host interactions can be analyzed much more precisely than is possible ...

Unraveling female resilience

Leveraging organ-on-chip technology to study the impact of menopause on immunological and metabolic resilience

04-Oct-2023 - Dynamic resilience, the ability of humans to withstand unexpected changes and stressors, is pivotal for maintaining bodily functions and overall health. Aging adults and especially women after menopause are at higher risk of adverse health outcomes (including frailty) in response to external ...

New organ-on-chip pilot seeks to reduce animal testing in consumer health industry

Cooperation between Bayer, the start-ups esqLABS and Dynamic42, and Placenta Lab of Jena University Hospital

08-Mar-2023 - A first-of-its-kind collaboration in the consumer health industry is developing a platform aimed at reducing or replacing animal testing using “organ-on-chip” (OoC) technology and interactive computational software. The pilot project, supported by esqLABS, Dynamic42, Placenta Lab of Jena ...

Controlling Cells with a Laser Beam

When biological tissue is created in the laboratory, nothing should be left to chance

31-May-2022 - At TU Wien, a method was developed to guide individual cells to the right place with laser precision. It is one of the biggest problems with producing artificial tissue: How can the individual cells be directed to the right place, for example when a blood vessel is to be created at a very ...

3D tissue structures on the chip act as organs in miniature

New organ-on-chip system enables precise monitoring of 3D tumour tissue outside the body

23-Feb-2022 - A research team around Dr. Andreas Weltin, Dr. Jochen Kieninger and Johannes Dornhof from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg has developed a system that, among other things, makes it possible to study the development of tumour cells outside the human ...

Retina-on-a-chip provides powerful tool for studying eye disease

29-Aug-2019 - Impact statement: New technology that recreates some of the complexity of the human retina may help scientists study eye disease and screen for drug side effects that harm the eye. The development of a retina-on-a-chip, which combines living human cells with an artificial tissue-like system, has ...

A Chip with Blood Vessels

14-Nov-2018 - Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way. Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, ...

3D 'organ on a chip' could accelerate search for new disease treatments

30-Oct-2018 - Researchers have developed a three-dimensional 'organ on a chip' which enables real-time continuous monitoring of cells, and could be used to develop new treatments for disease while reducing the number of animals used in research. The device, which incorporates cells inside a 3D transistor made ...