Structure analysis - 4 News from the science department by Uni Frankfurt am Main

Structure analysis - 4 News from the science department by Uni Frankfurt am Main

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X-ray snapshot: How light bends an active substance

An imaging technique established for decades applied to complex molecules for the first time

12-Mar-2025 - With the help of the world's most powerful X-ray laser, European XFEL, a research team led by Goethe University Frankfurt and the research centre DESY has achieved an important breakthrough: Using the example of the pharmaceutically active substance 2-thiouracil, they applied a long-established ...

structure analysis active ingredients molecules
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Molecular chaperones caught in flagrante

X-ray structure analysis shows how MHC I molecules are prepared for peptide loading

04-Oct-2022 - For an adequate immune response, it is essential that T lymphocytes recognise infected or degenerated cells. They do so by means of antigenic peptides, which these cells present with the help of specialised surface molecules (MHC I molecules). Using X-ray structure analysis, a research team from ...

structure analysis X-ray structure analysis immune system
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First image of antigen-bound T-cell receptor at atomic resolution

Basis for novel therapeutic approaches targeting severe diseases

22-Aug-2022 - T cells are our immune system’s customised tools for fighting infectious diseases and tumour cells. On their surface, these special white blood cells carry a receptor that recognises antigens. With the help of cryo-electron microscopy, biochemists and structural biologists from Goethe University ...

structure analysis antigens cancer
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Achilles’ heel of dangerous hospital pathogen discovered

Structural analysis revealed weak spots

06-Apr-2022 - A team from Research Unit 2251 of the German Research Foundation led by Goethe University has shed light on the structure of an enzyme important in the metabolism of the pathogenic bacterium Acinetobacter baumannii. The enzyme “MtlD” is critical for the bacterium’s synthesis of the sugar alcohol ...

structure analysis Acinetobacter baumannii antibiotic resistance
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