Customized programming of human stem cells

The results open new possibilities in research

02-Dec-2020 - Induced pluripotent stem cells (iPS) have the potential to convert into a wide variety of cell types and tissues. However, the "recipes" for this conversion are often complicated and difficult to implement. Researchers at the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden, Harvard ...

New informatics tool makes the most of genomic data

13-Jul-2018 - The rise of genomics, the shift from considering genes singly to collectively, is adding a new dimension to medical care; biomedical researchers hope to use the information contained in human genomes to make better predictions about individual health, including responses to therapeutic drugs. A ...

Cells communicate in a dynamic code

Important intercellular communication encodes and transmits more than thought

20-Feb-2018 - Multicellular organisms like ourselves depend on a constant flow of information between cells, coordinating their activities in order to proliferate and differentiate. Deciphering the language of intercellular communication has long been a central challenge in biology. Now, Caltech scientists ...

How a protein promotes cancer progression

14-Dec-2017 - Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex (LUBAC), regulating NFκB and other inflammatory molecules, SHARPIN ...

How Blood Vessels Are Formed

New insights into the development of the vascular system

18-Sep-2017 - New insights into the development of the vascular system: researchers in the team of Dr Carmen Ruiz de Almodóvar of the Heidelberg University Biochemistry Center have discovered a crucial biological step that regulates the formation of blood vessels. They were able to show that the proteins YAP ...

Repetitive elements shape embryonic chromatin landscape

30-Aug-2017 - Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly insignificant. Together with colleagues from the USA, scientists from the Helmholtz Zentrum München have now shown that ...

Shedding light on protein interaction networks in a developing organism

28-Jul-2017 - Researchers succeeded for the first time in mapping protein-protein interactions in living developing plant roots. The findings were made by three international research groups led by the department of Plant Developmental Biology at Wageningen University and Research. The work is considered a ...

Alzheimer's disease risk linked to a network of genes associated with myeloid cells

29-Jun-2017 - Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai. Mount Sinai researchers led an international, genome-wide study of more than 40,000 people ...

Scientists uncover how a cell's 'fuel gauge' promotes healthy development

27-Apr-2016 - Salk scientists have revealed how a cellular "fuel gauge" responsible for monitoring and managing cells' energy processes also has an unexpected role in development. This critical link could help researchers better understand cancer and diabetes pathways. This cellular fuel gauge is a protein ...

Tokyo Institute of Technology research: Towards medical treatments using cell level control

06-Nov-2012 - Researchers at Tokyo Institute of Technology and the Weizmann Institute of Science identify a means of controlling biological processes that could help treatments for immune disease, neurological disorders and cancer.The cellular response to a number of signals including inflammatory cytokines, ...