BioSystem Development and BAC BV collaborate to bring purification ligands to high throughput biotherapeutic process development

08-Nov-2010 - USA

BioSystem Development and BAC BV announced a collaboration to bring state-of-the-art high affinity ligands to the AssayMAP high-throughput micro-chromatography platform. This collaboration marks an essential objective toward growing a family of high-throughput tools for micro-scale purification and quantification of monoclonal antibodies.

The aim of the collaboration is to develop new tools and innovative solutions to purify and precisely quantify biotherapeutic antibodies in complex samples (such as cell culture supernatant and serum), a critical step in the manufacture of new biotherapeutics. BAC will contribute their proprietary CaptureSelect® Antibody Toolbox affinity ligands, based on Camelid single-chain antibody fragments. The unique properties of these ligands, such as high selectivity and distinctive binding characteristics, provide increased flexibility in the purification process of any antibody format.

BAC CEO, Dr. Laurens Sierkstra comments, “By combining BAC’s solutions for antibody purification with the AssayMAP high-throughput chromatography platform we enable researchers to optimize production and purification processes for their lead molecules early in the development process.”

BioSystem Development contributes the AssayMAP micro-chromatography platform, a patented cartridge separation system bridging complex chemistries with high-throughput, high-precision environments.

BSD’s Founder and CEO Scott Fulton stated, “This collaboration provides a scalable format with the CaptureSelect purification technology. We are starting with the CaptureSelect Fab kappa and Human Fc ligands to enable parallel, high-throughput purification and analysis of antibodies and fusions from any source, bringing this technology to bioprocess research and development.”

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Topic world Antibodies

Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous

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Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!

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View topic world
Topic World Chromatography

Topic World Chromatography

Chromatography enables us to separate, identify and thus understand complex substances. Whether in the food industry, pharmaceutical research or environmental analysis - chromatography opens up a treasure trove of information about the composition and quality of our samples. Discover the fascinating world of chromatography!

40+ products
5 whitepaper
35+ brochures