Greater Accuracy in Gauging Blood Coagulation
Fluorogenic Peptide-Based Substrates for Monitoring Thrombin Activity
In a collaborative project headed by Floris Rutjes (Radboud University Nijmegen, Netherlands), novel thrombin-specific fluorogenic peptides were developed for accurately determining thrombin concentrations by the TGT. Adding such a peptide substrate to a clotting plasma sample results in its hydrolysis by thrombin, thereby releasing the fluorophore. Spectrophotometric measurement of fluorophore release increases the sensitivity and thus accuracy of the TGT, yielding various essential coagulation parameters. The use of fluorogenic peptides in combination with the TGT is expected to find broad application in the field of haemostasis and thrombosis.
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