Oncgnostics GmbH obtains seed funding for financing preclinical and clinical trials
High-Tech Gründerfonds and STIFT invest into molecular cancer diagnostics from Jena
In the screening of cervical cancer, the first focus of oncgnostics, the Pap smear, in which abnormal cells are detected microscopically, is still almost exclusively applied. This method is very subjective, since detection of such abnormal cells requires a high degree of experience. Thus, Pap smear examination yields many false-positive and false-negative results. Detection of human papillomaviruses, which are the causative triggers of cervical cancer, by the so called HPV test, does not solve this problem: “Women currently not infected with HPV certainly have no disease, “ Dr. Alfred Hansel, biologist and one of the founders of oncgnostics, claims, “but most of the women who are tested HPV-positive are infected transiently. Only 10-15% of them have a disease which requires treatment.”
“Our approach utilizes the high negative predictive value of the HPV test and combines it with a test with which among HPV-positive women those are detected who have a precancerous lesion or cancer,” Martina Schmitz, biochemist and cofounder of oncgnostics, states. In genome-wide analyses the oncgnostics team has detected several suitable marker regions, which were then validated using well-characterized clinical samples from patients with or without cervical disease. Some of these markers are patent-pending.
The seed funding by the “High-Tech Gründerfonds (HTGF)” and the “Stiftung für Technologie, Innovation und Forschung Thüringen (STIFT)“ enables oncgnostics to develop diagnostically usable and saleable tests, with the aim to launch them in cooperation with HPV test suppliers. “The reflex test developed by oncgnostics enormously enhances the relevance of a positive HPV result, making the company an attractive partner even for established in vitro diagnostics companies,” adds Dr. Bernd Goergen, Senior Investment manager of the HTGF.
“We are glad to co-finance the business idea followed by oncgnostics, which has a high potential to close a prominent gap in diagnostics and to further strengthen the bio-region Jena”, Dr. Sven Günther, managing director of the STIFT, motivates the investment by the foundation.
During implementation of the project oncgnostics received exceptional support by the gynecology department of the university hospital Jena. “All women will benefit from a simple diagnostic test which has high sensitivity and specificity,” Professor Ingo Runnebaum, director of the gynecology department declares, “since upon early diagnosis cervical cancer is almost always curable, and we even may be able to maintain the woman’s ability to give birth.”
Oncgnostics GmbH was founded in Jena by Professor Matthias Dürst, leader of the gynaecological molecular biology lab, Alfred Hansel, Martina Schmitz, and the economist Kerstin Brox, on Feb 1st, 2012. The company focuses on the development of accurate molecular diagnostic tests for use in cancer screening, therapy decision, and follow-up care.
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Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.
Topic world Diagnostics
Diagnostics is at the heart of modern medicine and forms a crucial interface between research and patient care in the biotech and pharmaceutical industries. It not only enables early detection and monitoring of disease, but also plays a central role in individualized medicine by enabling targeted therapies based on an individual's genetic and molecular signature.