Study reveals protein to target in type 2 diabetes
To study the underlying mechanism, a team of researchers led by Narendra Wajapeyee, assistant professor of pathology, and Gerald Shulman, professor of cellular and molecular physiology and internal medicine, used a genomic technique to screen more than 600 proteins. They found that one of the proteins, MARCH1, impairs insulin by promoting the breakdown of the insulin receptor on the cell surface. MARCH1, which is increased in obese individuals, could be a promising new target for drugs to treat type 2 diabetes, they said. Lead authors on the study were Arvind Nagarajan and Max Petersen.
Original publication
Arvindhan Nagarajan, Max C. Petersen, Ali R. Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J. Jurczak, Michael R. Green, Gerald I. Shulman & Narendra Wajapeyee; "MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels"; Nature Comm.; 2016
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Original publication
Arvindhan Nagarajan, Max C. Petersen, Ali R. Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J. Jurczak, Michael R. Green, Gerald I. Shulman & Narendra Wajapeyee; "MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels"; Nature Comm.; 2016
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