4 News by Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) for the biotechnology industry

4 News by Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) for the biotechnology industry

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A new addition to the CRISPR toolbox: Teaching the gene scissors to detect RNA

Researchers present the PUMA technology for the precise detection of RNA with DNA-cutting Cas12 nucleases

18-Jul-2024 - CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have expanded this extensive toolbox. Their novel method, called PUMA, enables the ...

biomarkers CRISPR diagnostics
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Antimicrobial agents of the future

Researchers conducted the first systematic study of CRISPR-based antibiotics in Klebsiella pneumoniae

29-Apr-2024 - The antimicrobial potential of CRISPR-Cas systems is promising, yet how to best design or implement CRISPR nucleases remains poorly understood. An international team led by the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg has now addressed this knowledge gap. The ...

active ingredient research antibiotic resistance antibiotics
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When editing bacteria with CRISPR, less is more

Research team develops approach that increases efficiency of genome editing

13-Feb-2023 - Systematically attenuating DNA targeting activity can achieve CRISPR-driven editing in bacteria, greatly boosting colony counts and even increasing the frequency of precise genome editing. This was shown in a study of the Helmholtz Institute Würzburg (HIRI) in collaboration with the Helmholtz ...

bacteria CRISPR gene scissors
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New “decision aid” for CRISPR immune responses

Scientists show that target RNA levels influence defense against invaders

15-Jun-2022 - Friend or foe? Immune systems constantly face this question. They must recognize and clear foreign invaders without eliciting autoimmunity. Prokaryotic CRISPR-Cas systems recognize invaders based on genetic sequence. But what happens if the host genome shares the same sequences? A research team ...

CRISPR immune system RNA
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