Scientists from 33 European countries join forces to generate reference genomes for the continent's rich biological diversity

19-Sep-2024 - The European Reference Genome Atlas (ERGA) pilot project reports its success in uniting scientists from across Europe to produce high-quality reference genomes for 98 species. This marks a significant milestone in the quest to create a high-quality reference genome database for all European ...

A breakthrough in understanding COVID-19 proteins

Researchers have released a revolutionary database for molecular dynamics simulations

15-Jan-2024 - Designed to meet the urgent need for insights into the molecular intricacies of SARS-CoV-2 infection, BioExcel-CV19 is a repository for Molecular Dynamics (MD) simulations. Researchers at IRB Barcelona, led by Dr. Modesto Orozco, have built this database including key flexibility information ...

Self-teaching AI uses pathology images to find similar cases, diagnose rare diseases

New model acts as search engine for large databases of pathology images

14-Oct-2022 - Rare diseases are often difficult to diagnose and predicting the best course of treatment can be challenging for clinicians. Investigators from the Mahmood Lab at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, have developed a deep learning ...

Unchartered territory in the human genome

18-Jul-2022 - An international consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into genome databases in “Nature Biotechnology”. They could hold information about what sets humans apart from other animals. When researchers ...

Tapping the ocean as a source of natural products

New species and new molecules discovered

24-Jun-2022 - Using DNA data, ETH researchers have examined seawater to find not only new species of bacteria, but also previously unknown natural products that may one day prove beneficial. The oceans are teeming with countless forms of life, from the world’s largest creature – the blue whale– to miniscule ...

Speeding up sequence alignment across the tree of life

A sequence search engine for a new era of conservation genomics

09-Apr-2021 - A team of researchers from the Max Planck Institutes of Developmental Biology in Tübingen and the Max Planck Computing and Data Facility in Garching develops new search capabilities that will allow to compare the biochemical makeup of different species from across the tree of life. Its ...

A molecular map for the plant sciences

First comprehensive map of the proteome of the model plant Arabidopsis thaliana

16-Mar-2020 - Plants are essential for life on earth. They provide food for essentially all organisms, oxygen for breathing, and they regulate the climate of the planet. Proteins play a key role in controlling all aspects of life including plants. Under the leadership of the Technical University of Munich ...

Bioinformatics platform for the genome-based taxonomical classification of bacteria and archaea

Researchers develop Type Strain Genome Server (TYGS)

23-May-2019 - "TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy", is the title of the paper published in the current issue of the internationally journal Nature Communications. In this paper, Dr. Jan P. Meier-Kolthoff and Ass. Prof. Dr. Markus Göker, both of the ...

Looking deeper into brain function

New concept to discover the "operational functions" of brain areas

29-Mar-2018 - As neuroscience enters the era of big data bases, a new approach could offer a deeper and more systematic understanding of brain function, HBP scientists argue. To uncover connections between brain regions and specific cognitive functions, neuroscientists have long made extensive use of ...

New online tool gives 3-D view of human metabolic processes

28-Feb-2018 - An international team of researchers has developed a computational resource that provides a 3D view of genes, proteins and metabolites involved in human metabolism. Researchers used the tool to map disease-related mutations on proteins and also probed how genes and proteins change in response to ...