Unique immune-focused AI model creates largest library of inter-cellular communications

20-Jun-2018 - New data represents the largest ever analysis of immune cell signaling research, mapping more than 3,000 previously unlisted cellular interactions, and yielding the first ever immune-centric modular classification of diseases. These data serve to rewrite the reference book on immune-focused ...

Study of COPD patients has created a 'looking glass' into genome of pathogen

21-Mar-2018 - Decades of work on chronic obstructive pulmonary disease (COPD) at the University at Buffalo and the Veterans Affairs Western New York Healthcare System have yielded extraordinary information about the pathogen that does the most harm to patients. The results provide the first insights into how ...

New tool for tracking 'kiss-and-run' communication between cells

01-Feb-2018 - A new method for monitoring interactions between cells, dubbed LIPSTIC by its creators, is much more than a cosmetic improvement over existing techniques. The breakthrough, led by The Rockefeller University assistant professor Gabriel Victora , offers scientists in a wide range of disciplines a ...

Autoimmune disorders and regulatory B cells – marker identified

30-Jan-2018 - Autoimmune disorders such as rheumatism or type 1 diabetes are on the increase world-wide. Regulatory immune cells protect healthy individuals from the disorders and combat disease progression in affected individuals. So far, little is known about the group of regulatory B cells which play a role ...

Allergies? Exhausted regulatory T cells may play a role

28-Aug-2017 - Researchers have evidence that the specialized T cells responsible for maintaining a balanced immune response are vulnerable to exhaustion that disrupts normal functioning and may even contribute to allergic reactions. St. Jude Children's Research Hospital scientists led the study. The report is ...

How a few drops of blood led to a breakthrough in immunology

The roles of FOXP3 – a key gene in the regulation of our immune system

07-Jul-2017 - Scientists from the Research Institute of the McGill University Health Centre (RI-MUHC) may have cracked the code to understanding the function of special cells called regulatory T Cells.Treg cells, as they are often known, control and regulate our immune system to prevent excessive reactions. ...

PerkinElmer to acquire EUROIMMUN for approximately $1.3 Billion

19-Jun-2017 - PerkinElmer, Inc. announced that it has entered into a definitive agreement to acquireEUROIMMUN Medical Laboratory Diagnostics AG. The agreement provides that PerkinElmer will acquire up to a 100% stake in EUROIMMUN. The total purchase price of the transaction based on all outstanding shares ...

Membrane lipids hop in and out of rafts in the blink of an eye

New fluorescent lipids demonstrate how specialized regions in the cell membrane function

28-Mar-2017 - Researchers in Japan, India and France have found that molecules move into and out of a specialized region of the cell membrane, called the 'raft domain', at unexpectedly fast rates. The discovery was made possible by developing fluorescent compounds that are structurally similar to a special ...

How to amplify or stifle signals for immune responses

09-Mar-2017 - T cells, the managers of our immune systems, spend their days shaking hands with another type of cell that presents small pieces of protein from pathogens or cancerous cells to the T cell. But each T cell is programmed to recognize just a few protein pieces, known as antigens, meaning years can ...

New mechanism that leads to inflammation in rheumatoid arthritis discovered

03-Mar-2017 - New research findings suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients. Understanding the mechanisms of inflammation in rheumatoid arthritis is important for the design of new therapies for ...