Signatures of of heart attack - Multi-omics factor analysis provides new insights

Analysed for the first time: How does the immune system react to a heart attack?

23-May-2024 - Improving the outcome of patients after a heart attack is one of the major challenges of cardiology. This includes a comprehensive understanding of the pathophysiology and early detection of those patients who have a high risk of an unfavorable outcome. Researchers at LMU University Hospital, ...

High-tech vest monitors lung function

Machine learning algorithms aid with diagnosis

04-Aug-2022 - Patients with severe respiratory or lung diseases require intensive treatment and their lung function needs to be monitored on a continuous basis. As part of the Pneumo.Vest project, Fraunhofer researchers have developed a technology whereby noises in the lungs are recorded using a textile vest ...

Shining some light on the obscure proteome

Chemoproteomics draw the target landscape of HDAC drugs

01-Jul-2022 - Mass-spectrometry based proteomics is the big-data science of proteins that allows the monitoring of the abundance of thousands of proteins in a sample at once. Therefore, it is a particularly well-suited readout for discovering which proteins are targeted by any small molecule. An international ...

Researchers engineer cells to destroy malignant tumor cells but leave the rest alone

30-Jun-2021 - Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors. The modified "natural killer" cells can differentiate between cancer cells and healthy cells that are ...

Classifying Alzheimer's patients in 6 subgroups

"Alzheimer's, like breast cancer, is not one disease" - Shubhabrata Mukherjee

06-Dec-2018 - Researchers studying Alzheimer's disease have created an approach to classify patients with Alzheimer's disease, a finding that may open the door for personalized treatments. "Alzheimer's, like breast cancer, is not one disease," said lead author Shubhabrata Mukherjee, research assistant ...

Cancer identity technology makes it easier to find a tumor's 'address'

20-Nov-2018 - Purdue University researchers have developed a technology aimed at making it easier to deliver cancer treatment to the right "address" in the body while also easing the painful side effects of chemotherapy on patients. One of the big issues with chemotherapy is that most treatment approaches ...

How signals get inside cancer cells and spur aggressive growth

15-May-2018 - The outside of a cancer cell is bombarded by signals. They come from the immune system, supporting tissues and other structures. But how do those signals impact cancer? A new study provides a surprising model of the process by which those signals enter and influence the cell. The finding could ...

New device for low-cost single-cell analysis identifies fibroblast subtypes in RA patients

26-Feb-2018 - Single-cell analysis holds enormous potential to study how individual cells influence disease and respond to treatment, but the lack of cost-effective and user-friendly instrumentation remains challenging. As described in a study researchers at the New York Genome Center (NYGC) and New York ...

Changes in mouse breast tissue after exposure to fracking chemicals

07-Feb-2018 - In a study, environmental scientists led by Laura Vandenberg at the University of Massachusetts Amherst report that they observed changes in mammary gland development of female mice exposed during early development to the chemicals used in unconventional oil and gas (UOG) extraction - including ...

Computer program finds new uses for old drugs

20-Nov-2017 - Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts ...