How can we fight blood cancer more effectively?

Several hundred different treatment combinations to be tested simultaneously outside the body

02-May-2023 - Despite approved treatments being available, multiple myeloma remains incurable. But researchers at ETH Zurich and University Hospital Zurich set out to improve treatment outcomes by testing hundreds of existing therapeutics outside the body to predict their effectiveness. Multiple myeloma is a ...

AI analysis of cancer mutations may improve therapy

"A single test tells us something about the cellular mechanisms involved in cancer formation"

27-Jan-2023 - Combining single-cell data with a self-learning algorithm reveals how structural changes in chromosomes can trigger cancer. This new method could pave the way for personalized cancer treatments, writes a team led by Ashley Sanders in “Nature Biotechnology”. Cancer has many faces – no wonder, ...

New test to make gene therapy safer

SAGA detects tumour potential of viral vectors for blood stem cells

09-Jul-2021 - When the causes of serious diseases are based on a defective gene, medicine relies on gene therapy. In this strategy, defect-free genes are introduced into the body with the help of certain viruses. In this way, individual forms of congenital blindness, hereditary muscular atrophy or certain ...

Detailed tumour profiling

Better determine which treatment will best match every patient’s cancer and thus be most effective.

25-Jan-2021 - As part of a clinical study involving patients from the University Hospitals in Zurich and Basel, researchers are conducting a thorough and highly precise investigation into the molecular and functional properties of tumours. Their goal is to help physicians to better determine which treatment ...

Effective through AI in Transplantation Medicine: New Prediction Models for Disease Progression

Project network provides IT platform for clinical data integration, model development and validation

07-Mar-2019 - If radiation or chemotherapy treatment of leukaemias or lymphomas does not bring sufficient success, the transplantation of bone marrow or blood stem cells is usually the only chance of cure. Unfortunately, the majority of patients die despite transplantation, often due to spontaneous infections, ...

An errant editing enzyme promotes tumor suppressor loss and leukemia propagation

08-Jan-2019 - Researchers at University of California San Diego School of Medicine report that detection of "copy editing" by a stem cell enzyme called ADAR1, which is active in more than 20 tumor types, may provide a kind of molecular radar for early detection of malignancies and represent a new therapeutic ...

Genetic model identifies primary myelofibrosis outcomes

11-Dec-2017 - A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease. The group's findings ...

Research on crucial cutting enzyme maps sites of DNA damage in leukemias and other cancers

16-Jun-2017 - Researchers studying a DNA-cutting enzyme with a crucial role in regulating the structure of genes have discovered a broad role for its cutting activity in driving abnormal genetic rearrangements called translocations that cause cancer, including leukemias and solid tumors. The enzyme, type II ...

'Overturning established fact' leads to new new target in MLL-rearranged leukemia

15-Jun-2017 - The human gene MLL is named for the mixed lineage leukemia it creates. Specifically, the gene may break apart and fuse with parts from one of a number of other genes on other chromosomes to create cancer-causing translocations. These translocations make new proteins that have never been seen by ...

Taking a closer look at genetic switches in cancer

24-May-2017 - Many things go wrong in cells during the development of cancer. At the heart of the chaos are often genetic switches that control the production of new cells. In a particularly aggressive form of leukemia, called acute myeloid leukemia, a genetic switch that regulates the maturation of blood stem ...