PicoRuler: Molecular Rulers for High-Resolution Microscopy

Opening the Door to Investigate Complex Processes in Cells

04-Dec-2023 - Good news for researchers working with high-resolution fluorescence microscopy: Biocompatible molecular rulers are available for the first time to calibrate the latest super-resolution microscopy methods. Latest super-resolution microscopy methods now achieve an optical resolution in the range of ...

Hurdle of microscopy overcome

Smallest cell structures can now be imaged even better

10-Jul-2020 - High-resolution microscopy makes it theoretically possible to image cell structures with a resolution of a few nanometres. However, this has not yet been possible in practice. The reason for this is that antibodies carrying a fluorescent dye are usually used to mark the cell structures. The dye ...

Peptides as tags in fluorescence microscopy

Advance in biomedical imaging

01-Dec-2016 - The Biocenter of the University of Würzburg in close collaboration with the University of Copenhagen has developed an alternative approach to fluorescent tagging of proteins. The new probes are practicable and compatible with high-resolution microscopic procedures. Fluorescence microscopy ...

Microscopy: Nine at one blow

05-Feb-2016 - Advance in biomedical imaging: The University of Würzburg's Biocenter has enhanced fluorescence microscopy to label and visualise up to nine different cell structures simultaneously. Fluorescence microscopy allows researchers to visualise biomolecules in cells. They label the molecules using ...

Molecular learning machines under the microscope

21-Aug-2014 - Neurotransmitters play an important role in the communication of nerve cells. Major details of the processes involved have been unclear until recently. Scientists of the University of Würzburg have now shed light on these processes by using a new technique. All human thoughts, feelings and ...

Living cells made to fluoresce

13-Aug-2010 - Individual molecules and their dynamics can also be made visible in living cells using conventional fluorophores at a resolution of around 20 nanometers. How this is done is being revealed for the first time by researchers from Würzburg, Bielefeld, and New York in the journal Nature ...