Quality standards for looking into the tumor genome

First a letter salad, then a book

24-Sep-2024 - Personalized medicine with individually tailored therapies is becoming more and more a reality in cancer. This requires a precise look into the genetic material of tumors, a molecular diagnostic tumor profile. A research group from the German Network for Personalized Medicine (DNPM) has recorded ...

Complex green organisms emerged a billion years ago

Research team investigates the emergence of multicellularity

25-Jan-2024 - Of all the organisms that photosynthesize, land plants have the most complex bodies. How did this morphology emerge? A team of scientists led by the University of Göttingen has taken a deep dive into the evolutionary history of morphological complexity in streptophytes, which include land plants ...

Sophisticated gene memory: Researchers develop new method to genetically compare hundreds of animal species

02-May-2023 - Thanks to great technological advances, the genetic material of living beings can now be sequenced at a rapid rate. Comparisons of genomes, whether of closely related or completely different species, reveal particularly interesting findings. In this way, information can be obtained on ...

Pioneering method for stem cell diagnostics

Leif S. Ludwig receives Paul Ehrlich and Ludwig Darmstaedter Early Career Award

25-Jan-2023 - Biochemist and physician Dr Leif S. Ludwig (40) from the Berlin Institute of Health at Charité and the Max Delbrück Center will receive the 2023 Paul Ehrlich and Ludwig Darmstaedter Prize for Young Researchers, as the Scientific Council of the Paul Ehrlich Foundation announced. Ludwig has ...

Brain metastases in melanoma patients: important molecular mechanisms decoded

Different cell states determine progression of the disease

05-Jan-2023 - The development of brain metastases is a frequent occurrence in melanoma that is associated with a poor prognosis for the affected patients. The effectiveness of existing therapies varies greatly. The reasons for this variability, however, remain largely unknown. An international research team ...

Stem cell identity unmasked by single cell sequencing technology

31-May-2019 - Scientists from The University of Queensland's Diamantina Institute have revealed the difference between a stem cell and other blood vessel cells using gene-sequencing technology. Leading skin cancer and stem cell researcher Professor Kiarash Khosrotehrani said the findings provided evidence of ...

New test could identify resistant tuberculosis faster

19-May-2015 - The time needed to genetically sequence the bacteria causing tuberculosis (Mtb) from patient samples has been reduced from weeks to days using a new technique developed by a UCL-led team. This could help health service providers to better treat disease, control transmission of this infection, and ...

Merck Serono and Illumina Enter Strategic Collaboration for Diagnostics in Oncology

12-Mar-2015 - Merck Serono and Illumina, Inc., announced a collaboration to expand the development of a universal next-generation sequencing-based oncology diagnostic for clinical trials of targeted cancer therapies. Under the terms of the agreement, Merck Serono and Illlumina will work together to develop ...

Mutation detection in human in vitro fertilized embryos using whole-genome sequencing

12-Feb-2015 - Pre-implantation genetic diagnosis (PGD) is used in fertility clinics to detect large chromosomal abnormalities or genetic mutations passed on by parents to their in vitro fertilized (IVF) embryos. However, it is not possible to comprehensively scan the embryo's genome to detect spontaneous ...

New tool enhances the search for genetic mutations

27-Aug-2013 - Concealed within the vastness of the human genome, (comprised of some 3 billion base pairs), mutations are commonplace. While the majority of these appear to have neutral effect on human health, many others are associated with diseases and disease susceptibility. Reed Cartwright, a researcher at ...