A miniature magnetic resonance imager made of diamond

Quantum sensors make microscale NMR spectroscopy possible

23-Oct-2023 - The development of tumors begins with miniscule changes within the body's cells; ion diffusion at the smallest scales is decisive in the performance of batteries. Until now the resolution of conventional imaging methods has not been high enough to represent these processes in detail. A research ...

Shining some light on the obscure proteome

Chemoproteomics draw the target landscape of HDAC drugs

01-Jul-2022 - Mass-spectrometry based proteomics is the big-data science of proteins that allows the monitoring of the abundance of thousands of proteins in a sample at once. Therefore, it is a particularly well-suited readout for discovering which proteins are targeted by any small molecule. An international ...

Mass spectrometry-based draft of the mouse proteome

A milestone for biomedical research

30-Jun-2022 - Proteins control and organize almost every aspect of life. The totality of all proteins in a living organism, a tissue or a cell is called the proteome. Using mass spectrometry, researchers at the Technical University of Munich (TUM) characterize the proteome, or protein complement of the genome, ...

A molecular map for the plant sciences

First comprehensive map of the proteome of the model plant Arabidopsis thaliana

16-Mar-2020 - Plants are essential for life on earth. They provide food for essentially all organisms, oxygen for breathing, and they regulate the climate of the planet. Proteins play a key role in controlling all aspects of life including plants. Under the leadership of the Technical University of Munich ...

Milestone for the analysis of human proteomes

Synthetic peptides and spectra for proteomics

01-Feb-2017 - Researchers led by the Technical University of Munich (TUM) report on the synthesis of a library of more than 330,000 reference peptides representing essentially all canonical proteins of the human proteome. It is a major milestone in the ProteomeTools project which aims at translating human ...

The needle in the haystack

Immunotherapy for cancer: identifying suitable target antigens by mass spectrometry

19-Dec-2016 - New cancer therapies harness the immune system to fight tumors. One of the main principles behind these therapies is to find out precisely which molecules on cancer cells trigger an immune response. A team at the Technical University of Munich (TUM) and the Max Planck Institute of Biochemistry ...

200-year long dispute resolved: First direct evidence that elemental fluorine occurs in nature

09-Jul-2012 - Fluorine is the most reactive chemical element. That is why it is not found in nature in its elemental form, but only in compounds, such as fluorite – that was the accepted scientific doctrine so far. A special fluorite, the “fetid fluorite” or “antozonite”, has been the subject of many ...

New method for unraveling molecular structures

Residual dipolar couplings unveil structure of small molecules

22-Feb-2011 - Chemists at the Technische Universitaet Muenchen (TUM) and the Karlsruhe Institute of Technology (KIT) introduced a new method for identifying chemical compounds. The approach they used is an improvement on nuclear magnetic resonance (NMR) measurements – for decades one of the most successful ...

Metabolic fingerprints offer fresh clues and a new path toward personalized medicine

13-Apr-2010 - The old excuse, "I am only overweight because of my genes," is suddenly gaining credibility as researchers uncover ever more evidence that the way our bodies digest and process nutrients in the food we eat is different for every person. The budding discipline of metabolomics strives to ...