New test eliminates need for skin irritancy tests on rabbits
The two tests for skin irritation have been developed by industry and private companies and previously validated by ECVAM. The tests use in-vitro cell culture to evaluate the potential skin-irritancy of chemicals, by providing a realistic representation of the properties of human skin to identify irritant and non-irritant chemicals. These tests are the outcome of three years work involving 9 private and public organisations in the EU and US. The validation by ECVAM is an important step as it ensures that these tests can replace animal tests and at the same time provide the level of protection that consumers need against potentially harmful ingredients.
Two other tests validated today will identify eye irritants using tissues from slaughter-houses, which would otherwise be discarded. Here again, the test will replace the use of animals to identify severe irritants, though some animal testing will still be required for mild irritants. However, eight other models are currently under evaluation by ECVAM which if successful will completely replace testing on live rabbit's eyes. Work in this field is a joint effort with U.S. counterparts, which will ease international acceptance of the new tests.
These five tests are an important part of the European Commission's policy to reduce, replace and refine tests on animals in the EU. This policy is particularly relevant in the light of the latest amendment to the Cosmetics Directive, which will ban the testing of cosmetic ingredients on animals from 2009, as well as the forthcoming REACH Chemicals legislation, which comes into force on 1 June 2007.
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